EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) induced by EDTA anticoagulants is a common laboratory phenomenon. It is caused by in-vitro PLT aggregation and may lead to a low PLT result and, ultimately, misdiagnosis and wrong medical treatment for the patient. In the previous...

Clinical Significance Derived from megakaryocytes, platelets (PLT) are produced and matured in the bone marrow. Besides widely known thrombosis and wound repair, PLT also plays important roles in inflammation, immunity and cancer biology[1]. Normal reference intervals of PLT in peripheral...

When the platelet (PLT) count is extremely low, is platelet transfusion really required? Let’s analyze the following case, which tells us a different answer. Case background A 49-year-old woman went to the emergency department due to transient cognitive disorder. She...

When the platelet value is low, patients are at risk of bleeding. Bleeding in vital organs is life-threatening. According to Giuseppe Lippi and other professors, there is no universal agreement on the definition of platelet transfusion thresholds.[1] However, the degree...

Ethylenediaminetetraacetic Acid – Pseudothrombocytopenia (EDTA-PTCP) is a laboratory artifact that may lead to an incorrect evaluation and unnecessary treatment of patients. Which of the following method (or methods) would you take to correct platelet counts in case of an EDTA-induced...

Thrombocytopenia is a condition characterized by abnormally low levels of platelets in the blood. However, falsely low platelet counts, or pseudothrombocytopenia (PTCP), though easily unrecognized, are found in clinical cases. It is an in vitro phenomenon caused by platelet clumping...

Three routine laboratory tests Blood, urine and feces analysis are the three common tests in clinical laboratories. Among them, blood testing is the most important way to keep track of one’s overall physical well-being. In the past, routine blood tests...

Quick Facts about Malaria According to the World Health Organization (WHO), there were an estimated 241 million cases of malaria worldwide in 2020, and the estimated number of malaria deaths stood at 627,000 in that year. The African Region was...

In the last two chapters, we talked about what ESR is and the applications of ESR, CRP and CBC analysis. ESR is an acute phase reactant and serves as a marker for inflammation. It correlates with disease activity and response...

Hemostasis and coagulation are the main functions of platelets (PLTs). Thrombocytopenia is a common cause of bleeding. A PLT count from 20 to 50×109/L may indicate mild or surgical bleeding. If it is lower than 20×109/L, this may indicate severe...